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Article

Dissecting heritability, environmental risk, and air pollution causal effects using > 50 million individuals in MarketScan.

Nature communications - 25 Jun 2024

McGuire Daniel, Markus Havell, Yang Lina, Xu Jingyu, Montgomery Austin, Berg Arthur, Li Qunhua, Carrel Laura, Liu Dajiang J, Jiang Bibo

Abstract excerpt

Large national-level electronic health record (EHR) datasets offer new opportunities for disentangling the role of genes and environment through deep phenotype information and approximate pedigree structures. Here we use the approximate geographical locations of patients as a proxy for spatially correlated community-level environmental risk factors. We develop a spatial mixed linear effect (SMILE) model that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38918381
DOI: 10.1038/s41467-024-49566-6
PMCID: PMC11199552

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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