Genetically informed causal links between gut microbiota and bone mass: pleiotropy and metabolic mediation.

doi:10.1038/s41467-025-66881-8

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Article

Genetically informed causal links between gut microbiota and bone mass: pleiotropy and metabolic mediation.

Nature communications - 28 Nov 2025

Guan Peng-Lin, Yuan Cheng-Da, Han Ming-Yu, Fang Yi-Hu, Yu Chun-Fu, Zhao Pian-Pian, Qian Yu, Xia Jiang-Wei, Wei Peng, Liu Cai-Rui, Yang Meng-Yuan, Xu Wei, Cheung Ching-Lung, Xie Shu-Yang, Zhou Fu-Sheng, Rong Xiao-Li, Zheng Hou-Feng

Abstract excerpt

The interplay among host genetic architecture, gut microbiota, metabolites and bone metabolism remains poorly understood. This study aims to comprehensively investigate the shared genetic factors, causal relationships, and the involvement of blood metabolites between gut microbiota and bone mass, based on datasets from European populations. Here, we estimate the polygenic SNP heritability for 1104 gut microbiota...

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Bifidobacterium
Bone and Bones
Bone Density
Gastrointestinal Microbiome
Genetic Pleiotropy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Host Microbial Interactions

Lactose Intolerance

Multifactorial Inheritance

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PMID: 41315359
DOI: 10.1038/s41467-025-66881-8
PMCID: PMC12753762

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LCT
MCM6

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