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Gut microbiota, plasma metabolites, and osteoporosis: unraveling links via Mendelian randomization

15 Jul 2024

Abstract excerpt

Objective: Osteoporosis, characterized by reduced bone density and heightened fracture risk, is influenced by genetic and environmental factors. This study investigates the interplay between gut microbiota, plasma metabolomics, and osteoporosis, identifying potential causal relationships mediated by plasma metabolites. Methods: Utilizing aggregated genome-wide association studies (GWAS) data, a comprehensive...

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PMID: 39077745
DOI: 10.3389/fmicb.2024.1433892

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