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Article

Mitochondrial stress engages E2F1 apoptotic signaling to cause deafness.

Cell - 17 Feb 2012

Raimundo Nuno, Song Lei, Shutt Timothy E, McKay Sharen E, Cotney Justin, Guan Min-Xin, Gilliland Thomas C, Hohuan David, Santos-Sacchi Joseph, Shadel Gerald S

Abstract excerpt

Mitochondrial dysfunction causes poorly understood tissue-specific pathology stemming from primary defects in respiration, coupled with altered reactive oxygen species (ROS), metabolic signaling, and apoptosis. The A1555G mtDNA mutation that causes maternally inherited deafness disrupts mitochondrial ribosome function, in part, via increased methylation of the mitochondrial 12S rRNA by the methyltransferase...

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Source

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Identifiers

PMID: 22341444
DOI: 10.1016/j.cell.2011.12.027
PMCID: PMC3285425

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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