Mutational and copy number analysis at diagnosis and relapse of mantle cell lymphoma.

doi:10.3324/haematol.2024.286813

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Article

Mutational and copy number analysis at diagnosis and relapse of mantle cell lymphoma.

Haematologica - 1 Aug 2026

Joffe Erel, Uppal Manik, Zheng Serena, Bantilan Kurt S, Batlevi Connie, Epstein-Peterson Zachary, Ghione Paola, Hamlin Paul, Matasar Matthew, Moskowitz Alison, Noy Ariela, Palomba Maria L, Keudell Gotfried Von, Falchi Lorenzo, Yahalom Joachim, Segodin Vitaly, Kotlov Nikita, Egorov Evgeniy, Degryse Sandrine, Bagaev Aleksander, Fowler Nathan, Arcila Maria, Dogan Ahmet, Salles Gilles, Kumar Anita, Zelenetz Andrew D

Abstract excerpt

Most patients diagnosed with mantle cell lymphoma (MCL) experience extended remissions following frontline chemoimmunotherapy, yet with extended follow-up, relapses seem nearly inevitable. This study aimed to define the genomic landscape of MCL at diagnosis and relapse and investigate the clonal evolutionary dynamics associated with progression of disease (POD). We conducted comprehensive genomic sequencing on...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41307120
DOI: 10.3324/haematol.2024.286813
PMCID: PMC13482259

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