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Mendelian randomization and colocalization analyses reveal an association between diet consumption and altered telomere length in leukocytes.

Medicine - 21 Nov 2025

Wang Bowen, He Jiawei, Pei Zijuan, Tao Chunhui, Song Enfeng

Abstract excerpt

Observational studies suggest dietary factors influence leukocyte telomere length (LTL), yet causality remains unproven. Using Mendelian randomization (MR) and colocalization analyses, we investigated causal relationships between 38 dietary phenotypes and LTL to clarify conflicting evidence on Mediterranean diet (MD) components (alcohol, nuts) and biological aging. Genetic instruments for dietary exposures were...

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Alcohol Drinking
Diet, Mediterranean
Genome-Wide Association Study
Leukocytes
Mendelian Randomization Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Telomere Shortening

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PMID: 41305752
DOI: 10.1097/MD.0000000000045825
PMCID: PMC12643740

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