Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Investigating HLA haplotypes as a potential risk factor for nodding syndrome: A case-control study in the Mahenge area, Tanzania.

PLoS neglected tropical diseases - 1 Nov 2025

Hadermann Amber, Bhwana Dan, Mhina Athanas D, Amaral Luís-Jorge, Siewe Fodjo Joseph N, Emonds Marie-Paule, Weckhuysen Sarah, Mmbando Bruno P, Colebunders Robert

Abstract excerpt

BACKGROUND: Nodding syndrome (NS) is a disabling childhood-onset epilepsy occurring in onchocerciasis-endemic regions. High Onchocerca volvulus microfilarial loads in childhood are a key risk factor, but not all heavily infected individuals develop NS, suggesting a possible role for host genetic susceptibility. Human leukocyte antigen (HLA) haplotypes have been implicated in susceptibility to various infectious...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Case-Control Studies
Share to Child

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Child, Preschool

Share to Haplotypes

Share to HLA Antigens

Share to Risk Factors

Share to Tanzania

Share to Young Adult

Source

Open in PubMed Open full text

Identifiers

PMID: 41296809
DOI: 10.1371/journal.pntd.0012971
PMCID: PMC12680330

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Investigating HLA haplotypes as a potential risk factor for nodding syndrome: A case-control study in the Mahenge area, Tanzania.PMID 41296809Read ↗

Macrophage migration inhibitory factor in Nodding syndrome.Semantic proximity Read ↗

HLA-DQ alleles associate with cutaneous features of onchocerciasis. The Kaduna-London-Manchester Collaboration for Research on Onchocerciasis.Semantic proximity Read ↗

Onchocerciasis-associated epilepsy in the Democratic Republic of Congo: Clinical description and relationship with microfilarial densitySemantic proximity Read ↗

Nodding syndrome phenotypes.Semantic proximity Read ↗

Insights Into Onchocerca volvulus Population Biology Through Multilocus Immunophenotyping.Semantic proximity Read ↗

Association of HLA and post-schistosomal hepatic disorder: a systematic review and meta-analysis.Semantic proximity Read ↗

Association between HLA class I and class II alleles and the outcome of West Nile virus infection: an exploratory study.Semantic proximity Read ↗

The Neurocognitive Burden of Onchocerciasis-associated Epilepsy in an onchocerciasis-endemic zone in Cameroon: a case-control studySemantic proximity Read ↗

Exposure to parasitic infections is associated with features and phenotypes of active convulsive epilepsy in AfricaSemantic proximity Read ↗

Hyperreactive Onchocerciasis is Characterized by a Combination of Th17-Th2 Immune Responses and Reduced Regulatory T CellsSemantic proximity Read ↗

HLA-DRB1∗1502 Is Associated With Anti-N-Methyl-D-aspartate Receptor Encephalitis in Thai Children.Semantic proximity Read ↗

Association of a NOD2 gene polymorphism and T-helper 17 cells with presumed ocular toxoplasmosis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.