Article
Insights Into Onchocerca volvulus Population Biology Through Multilocus Immunophenotyping.
The Journal of infectious diseases - 15 Sept 2017
Norice-Tra Carmelle T, Ribeiro José, Bennuru Sasisekhar, Fay Michael P, Tyagi Rahul, Mitreva Makedonka, Nutman Thomas B
Abstract excerpt
We have developed a serologically based immunophenotyping approach to study Onchocerca volvulus (Ov) population diversity. Using genomic sequence data and polymerase chain reaction-based genotyping, we identified nonsynonymous single-nucleotide polymorphisms (SNPs) in the genes of 16 major immunogenic Ov proteins: Ov-CHI-1/Ov-CHI-2, Ov16, Ov-FAR-1, Ov-CPI-1, Ov-B20, Ov-ASP-1, Ov-TMY-1, OvSOD1, OvGST1, Ov-CAL-1,...
Topics
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Animals
- Antibodies, Helminth
- Antibody Formation
- Antigens, Helminth
- Child
- DNA, Protozoan
- Female
- Genetics, Population
- Genotyping Techniques
- Helminth Proteins