Article
Association between HLA class I and class II alleles and the outcome of West Nile virus infection: an exploratory study.
PloS one - 1 Jan 2011
Lanteri Marion C, Kaidarova Zhanna, Peterson Trevor, Cate Steven, Custer Brian, Wu Shiquan, Agapova Maria, Law Jacqueline P, Bielawny Thomas, Plummer Frank, Tobler Leslie H, Loeb Mark, Busch Michael P, Bramson Jonathan, Luo Ma, Norris Philip J
Abstract excerpt
BACKGROUND: West Nile virus (WNV) infection is asymptomatic in most individuals, with a minority developing symptoms ranging from WNV fever to serious neuroinvasive disease. This study investigated the impact of host HLA on the outcome of WNV disease. METHODS: A cohort of 210 non-Hispanic mostly white WNV(+) subjects from Canada and the U.S. were typed for HLA-A, B, C, DP, DQ, and DR. The study subjects were...
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