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Machine learning and multi-omics analysis reveal key regulators of proneural–mesenchymal transition in glioblastoma

5 Jun 2025

Abstract excerpt

Glioblastoma (GBM) is classified into subtypes according to the molecular expression profile; the proneural subtype has a relatively good prognosis, and the mesenchymal type is the most aggressive form with the worst prognosis. GBM undergoes proneural-mesenchymal transition (PMT) during its evolution or in response to changes in the microenvironment or therapeutic interventions. PMT is accompanied by infiltration...

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PMID: 40473799
DOI: 10.1038/s41598-025-04862-z

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