Article
Incorporation of Genomic Determinants Improves Diagnostic Accuracy of Oligomonocytic Chronic Myelomonocytic Leukemia.
Blood cancer discovery - 5 May 2026
Montalban-Bravo Guillermo, Wu Chong, Rodriguez-Sevilla Juan Jose, Wei Yue, Chien Kelly S, Bouligny Ian, Kanagal-Shamanna Rashmi, Li Ziyi, Natu Anuya, Gurney Mark, Bazinet Alexandre, Hammond Danielle, Bataller Alex, Borthakur Gautam, Short Nicholas J, DiNardo Courtney D, Kadia Tapan M, Ravandi Farhad, Daver Naval, Pemmaraju Naveen, Jabbour Elias, Issa Ghayas C, Wang Sa A, Patel Keyur P, Tang Guilin, Medeiros L Jeffrey, Lasho Terra L, Finke Christy M, Al-Kali Aref, Csizmar Clifford M, Alkhateeb Hassan, Gangat Naseema, Mangaonkar Abhishek A, Roman-Bravo David, Arenillas Leonor, Tefferi Ayalew, Kantarjian Hagop M, Garcia-Manero Guillermo, Calvo Xavier, Patnaik Mrinal M, Loghavi Sanam
Abstract excerpt
Recent updates to monocyte count thresholds recognize oligomonocytic chronic myelomonocytic leukemia (OM-CMML) as an early form of CMML. However, the clinical validity of these changes remains uncertain without incorporating biological and genomic factors. In this study, we analyzed a cohort of 911 patients (249 with OM-CMML, 359 with overt CMML, and 303 with myelodysplastic syndromes) using unsupervised...
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