Autophagy activation by the Becn1F121A mutation reprograms neuroinflammation and promotes neurological recovery after spinal cord injury.

doi:10.1016/j.bbi.2025.106191

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Autophagy activation by the Becn1F121A mutation reprograms neuroinflammation and promotes neurological recovery after spinal cord injury.

Brain, behavior, and immunity - 1 Jan 2026

Lei Zhuofan, Li Yun, Li Hui, Wu Junfang

Abstract excerpt

Autophagy is essential for maintaining cellular homeostasis, particularly under stress conditions such as neurotrauma. In experimental models of spinal cord injury (SCI), dysregulated autophagy has been closely associated with secondary injury cascades. Our previous work demonstrated that post-injury inflammation is exacerbated by genetic inhibition of autophagy and alleviated by pharmacological enhancement....

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PMID: 41271189
DOI: 10.1016/j.bbi.2025.106191
PMCID: PMC12821155

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