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Article

Stimulation of autophagy by rapamycin protects neurons from remote degeneration after acute focal brain damage

1 Feb 2012

Abstract excerpt

Autophagy is the evolutionarily conserved degradation and recycling of cellular constituents. In mammals, autophagy is implicated in the pathogenesis of many neurodegenerative diseases. However, its involvement in acute brain damage is unknown. This study addresses the function of autophagy in neurodegeneration that has been induced by acute focal cerebellar lesions. We provide morphological, ultrastructural, and...

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PMID: 22248716
DOI: 10.4161/auto.8.2.18599

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