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Integrative Analysis of the Inflammatory Bowel Disease Serum Metabolome Improves Our Understanding of Genetic Etiology and Points to Novel Putative Therapeutic Targets.

Gastroenterology - 1 Mar 2022

Di'Narzo Antonio F, Houten Sander M, Kosoy Roman, Huang Ruiqi, Vaz Frédéric M, Hou Ruixue, Wei Gabrielle, Wang Wenhui, Comella Phillip H, Dodatko Tetyana, Rogatsky Eduard, Stojmirovic Aleksandar, Brodmerkel Carrie, Perrigoue Jacqueline, Hart Amy, Curran Mark, Friedman Joshua R, Zhu Jun, Agrawal Manasi, Cho Judy, Ungaro Ryan, Dubinsky Marla C, Sands Bruce E, Suárez-Fariñas Mayte, Schadt Eric E, Colombel Jean-Frédéric, Kasarskis Andrew, Hao Ke, Argmann Carmen

Abstract excerpt

BACKGROUND & AIMS: Polygenic and environmental factors are underlying causes of inflammatory bowel disease (IBD). We hypothesized that integration of the genetic loci controlling a metabolite's abundance, with known IBD genetic susceptibility loci, may help resolve metabolic drivers of IBD. METHODS: We measured the levels of 1300 metabolites in the serum of 484 patients with ulcerative colitis (UC) and 464...

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Acyl-CoA Dehydrogenase
Butyrates
Colitis, Ulcerative

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mendelian Randomization Analysis

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PMID: 34780722
DOI: 10.1053/j.gastro.2021.11.015
PMCID: PMC9214725

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