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Article

Caffeine exacerbates exercise-induced gut cell damage and is influenced by ADORA2A genotype but not CYP1A2 genotype: A preliminary study.

Physiological reports - 1 Nov 2025

Davison Glen, Carswell Alexander T, Baron Pauline, Martinez-Gonzalez Borja

Abstract excerpt

Endurance exercise may be associated with acute damage to intestinal epithelial cells. The effect of caffeine supplementation, and whether this is influenced by common genetic polymorphisms (ADORA2A: rs5751876 and CYP1A2: rs762551), is not currently known. Participants (n = 18 men and women) ingested caffeine (3 mg/kg body mass) or placebo 45 min before cycling (20 min at 70% maximal oxygen uptake followed by a...

Read the complete abstract on PubMed

Topics

Humans

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Male

Caffeine

Female

Cytochrome P-450 CYP1A2

Exercise

Receptor, Adenosine A2A

Adult

Young Adult

Genotype

Fatty Acid-Binding Proteins

Intestinal Mucosa

Source

Open in PubMed Open full text

Identifiers

PMID: 41261949
DOI: 10.14814/phy2.70673
PMCID: PMC12631023

Genes

ADORA2A
CYP1A2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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