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Article

Exonic Variation in HLA-C, CFB, and TAP2 Associated With Increased Risk for Comorbid Crohn's Disease and Psoriasis.

International journal of dermatology - 1 Mar 2026

Shaw Vikram R, Byun Jinyoung, Zhu Catherine, Sninsky Jared, Han Younghun, Cohen Jeffrey M, Amos Christopher I

Abstract excerpt

BACKGROUND: Psoriasis (PS) and Crohn's disease (CD) are chronic immune-mediated inflammatory diseases with overlapping immunologic mechanisms. Although comorbidity is rare, epidemiologic and genetic studies have highlighted a significant association between PS and CD. METHODS: We performed a focused exome-wide association study (ExWAS) comparing individuals with comorbid PS and CD to healthy controls...

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Topics

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Share to ATP Binding Cassette Transporter, Subfamily B, Member 3
Share to Comorbidity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Crohn Disease

Share to HLA-C Antigens

Share to Mutation, Missense

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Source

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Identifiers

PMID: 41258759
DOI: 10.1111/ijd.70160
PMCID: PMC12892109

Genes

CFB
TAP2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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