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Article

NLRP7 participates in the human subcortical maternal complex and its variants cause female infertility characterized by early embryo arrest.

Journal of molecular medicine (Berlin, Germany) - 1 Jun 2023

Han Jian, Zhang Nana, Cao Qiqi, Shi Xiaodan, Wang Congjing, Rui Ximan, Ding Jie, Zhao Chun, Zhang Junqiang, Ling Xiufeng, Li Hong, Guan Yichun, Meng Qingxia, Huo Ran

Abstract excerpt

Successful human reproduction requires normal oocyte maturation, fertilization, and early embryo development. Early embryo arrest is a common phenomenon leading to female infertility, but the genetic basis is largely unknown. NLR family pyrin domain-containing 7 (NLRP7) is a member of the NLRP subfamily. Previous studies have shown that variants of NLRP7 are one of the crucial causes of female recurrent...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 37148315
DOI: 10.1007/s00109-023-02322-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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