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Article

Cardiac Fibroblast-Specific Activating Transcription Factor 3 Protects Against Heart Failure by Suppressing MAP2K3-p38 Signaling.

Circulation - 23 May 2017

Li Yulin, Li Zhenya, Zhang Congcong, Li Ping, Wu Yina, Wang Chunxiao, Bond Lau Wayne, Ma Xin-Liang, Du Jie

Abstract excerpt

BACKGROUND: Hypertensive ventricular remodeling is a common cause of heart failure. However, the molecular mechanisms regulating ventricular remodeling remain poorly understood. METHODS: We used a discovery-driven/nonbiased approach to identify increased activating transcription factor 3 (ATF3) expression in hypertensive heart. We used loss/gain of function approaches to understand the role of ATF3 in heart...

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Share to Angiotensin II
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Heart Failure

Share to Histone Deacetylase 1

Share to Hypertrophy, Left Ventricular

Share to p38 Mitogen-Activated Protein Kinases

Share to Ventricular Function, Left

Share to Ventricular Remodeling

Source

Open in PubMed Open full text

Identifiers

PMID: 28249877
DOI: 10.1161/CIRCULATIONAHA.116.024599
PMCID: PMC5542579

Genes

ATF3
HDAC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Cardiac Fibroblast-Specific Activating Transcription Factor 3 Protects Against Heart Failure by Suppressing MAP2K3-p38 Signaling.PMID 28249877Read ↗

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