Article
Two separate Ni(2+) -sensitive voltage-gated Ca(2+) channels modulate transretinal signalling in the isolated murine retina.
Acta ophthalmologica - 1 Nov 2011
Alnawaiseh Maged, Albanna Walid, Chen Chien-Chang, Campbell Kevin P, Hescheler Jürgen, Lüke Matthias, Schneider Toni
Abstract excerpt
PURPOSE: Light-evoked responses from vertebrate retinas were recorded as an electroretinogram (ERG). The b-wave is the most prominent component of the ERG, and in the bovine retina its NiCl(2) -sensitive component was attributed to reciprocal signalling by pharmacoresistant R-type voltage-gated Ca(2+) channels, which similar to other voltage-dependent Ca(2+) channels trigger and control neurotransmitter release....
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