Article

Differential impact of Kv8.2 loss on rod and cone signaling and degeneration

2021-07-06

Abstract excerpt

<h4>ABSTRACT</h4> Heteromeric Kv2.1/Kv8.2 channels are voltage-gated potassium channels localized to the photoreceptor inner segment. They carry I Kx , which is largely responsible for setting the photoreceptor resting membrane potential. Mutations in Kv8.2 result in childhood-onset Cone Dystrophy with Supernormal Rod Response (CDSRR). We generated a Kv8.2 knockout (KO) mouse and examined retinal signaling and p...

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Identifiers and source

Literature Corpus work: 56040a88-1dfa-589e-95ac-995fb1caa2fd
DOI: 10.1101/2021.07.05.451197

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