Mutations with residual CFTR function are associated with better glucose tolerance and insulin secretion in people with Cystic fibrosis.

doi:10.1016/j.jcf.2025.11.001

Article

Mutations with residual CFTR function are associated with better glucose tolerance and insulin secretion in people with Cystic fibrosis.

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society - 1 Mar 2026

Ciciriello Fabiana, Foppiani Andrea, Sileo Federica, Alghisi Federico, Russo Maria Chiara, Claut Laura Elisabetta, Bisogno Arianna, Costa Stefano, Lucanto Maria Cristina, Lucidi Vincenzina, Colombo Carla, Battezzati Alberto

Abstract excerpt

BACKGROUND: People with Cystic Fibrosis (pwCF) often exhibit impaired insulin secretion, which may lead to Cystic Fibrosis-Related Diabetes (CFRD). The impact of CF variants in the complex relationship between CFTR channel function, pancreatic function, and glucose metabolism remains only partially understood. METHODS: In this multicenter study, 341 pwCF (57 % females, 79 % with pancreatic insufficiency; median...

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Mutations with residual CFTR function are associated with better glucose tolerance and insulin secretion in people with Cystic fibrosis.

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