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Article

Preservation of β-cell Function in Pancreatic Insufficient Cystic Fibrosis With Highly Effective CFTR Modulator Therapy.

The Journal of clinical endocrinology and metabolism - 21 Dec 2023

Flatt Anneliese J, Sheikh Saba, Peleckis Amy J, Alvarado Paola, Hadjiliadis Denis, Stefanovski Darko, Gallop Robert J, Rubenstein Ronald C, Kelly Andrea, Rickels Michael R

Abstract excerpt

CONTEXT: Elexacaftor/tezacaftor/ivacaftor (ETI; Trikafta) enhances aberrant cystic fibrosis transmembrane conductance regulator function and may improve the insulin secretory defects associated with a deterioration in clinical outcomes in pancreatic insufficient cystic fibrosis (PI-CF). OBJECTIVE: This longitudinal case-control study assessed changes in β-cell function and secretory capacity measures over 2...

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Identifiers

PMID: 37503734
DOI: 10.1210/clinem/dgad443
PMCID: PMC10735317

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Preservation of β-cell Function in Pancreatic Insufficient Cystic Fibrosis With Highly Effective CFTR Modulator Therapy.PMID 37503734Read ↗

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CFTR modulators increase risk of acute pancreatitis in pancreatic insufficient patients with cystic fibrosis.Semantic proximity Read ↗

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The Impact of Highly Effective CFTR Modulators on Growth and Nutrition Status.Semantic proximity Read ↗

Energy Balance and Mechanisms of Weight Gain with Ivacaftor Treatment of Cystic Fibrosis Gating Mutations.Semantic proximity Read ↗

Mutations with residual CFTR function are associated with better glucose tolerance and insulin secretion in people with Cystic fibrosis.Semantic proximity Read ↗

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