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Article

Differential Performance of Polygenic Score for Coronary Artery Disease Based on Coronary Artery Calcium Between Men Living With and Without HIV.

Journal of the American Heart Association - 18 Nov 2025

Wojcik Genevieve, Arvanitis Marios, Haberlen Sabina, Kim Eun-Young, Kim Heejin, Nam Kireem, Feinstein Matthew J, Wolinsky Steven, Margolick Joseph B, Budoff Matthew, Magnani Jared W, Duggal Priya, Post Wendy S

Abstract excerpt

BACKGROUND: Individuals with HIV have increased risk for coronary artery disease (CAD). However, the utility of the polygenic risk score (PRS) for estimating CAD risk (PRSCAD) is unknown in people living with HIV (PLWH). We evaluated the performance of PRSCAD on coronary artery calcium (CAC), a measure of subclinical atherosclerosis, by HIV serostatus. METHODS: A PRSCAD was applied to 1071 men (PLWH, n=659;...

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Identifiers

PMID: 41220122
DOI: 10.1161/JAHA.125.045144
PMCID: PMC12887214

Genes

CAD

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