Article
Association of a polygenic risk score with low trauma fractures in people with HIV - The swiss HIV cohort study.
PloS one - 1 Jan 2026
Strickler Claudio, Thorball Christian W, Schoepf Isabella C, Schwenke Johannes, Hasse Barbara, Ryom Lene, Thurnheer Maria C, Fux Christoph, Kahlert Christian R, Bernasconi Enos, Calmy Alexandra, Lamy Olivier, Günthard Huldrych F, Ledergerber Bruno, Fellay Jacques, Tarr Philip E
Abstract excerpt
BACKGROUND: Polygenic risk scores (PRS) are likely to enter routine clinical care for individual disease risk prediction in the next 10 years. We recently showed that the bone mineral density-associated gSOS-PRS is independently associated with a > 4-fold increased risk of osteoporosis in the Swiss HIV Cohort Study (SHCS). Here we investigate whether this PRS is also associated with low trauma fractures (LTF) in...
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