Article
Genomic risk prediction of type 2 diabetes in people living with and without HIV.
Scientific reports - 22 Jan 2026
Armstrong Nicole D, Srinivasasainagendra Vinodh, Pilla Lavanya, Gangaraju Radhika, Hunt Peter W, Nance Robin M, Crane Heidi M, Peter Inga, Heath Sonya L, Burkholder Greer A, Moore Richard D, Jacobson Jeffrey M, Cachay Edward R, Davy-Mendez Thibaut, Iwaki Hirotaka, Sargent Lana, Tiwari Hemant K, Irvin Marguerite R
Abstract excerpt
Type 2 diabetes (T2D) risk prediction remains a challenge, particularly in underrepresented populations, including people living with HIV (PWH) and those of non-European ancestry. We evaluated the performance of two metaPRS (polygenic risk score) models, integrating genetic markers related to inflammation and lipid metabolism, in predicting T2D risk across ancestry groups (African and European), with and without...
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