Coronary Artery Disease-Associated and Longevity-Associated Polygenic Risk Scores for Prediction of Coronary Artery Disease Events in Persons Living With Human Immunodeficiency Virus: The Swiss HIV Cohort Study.

doi:10.1093/cid/ciab521

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Coronary Artery Disease-Associated and Longevity-Associated Polygenic Risk Scores for Prediction of Coronary Artery Disease Events in Persons Living With Human Immunodeficiency Virus: The Swiss HIV Cohort Study.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 2 Nov 2021

Schoepf Isabella C, Thorball Christian W, Ledergerber Bruno, Engel Tanja, Raffenberg Marieke, Kootstra Neeltje A, Reiss Peter, Hasse Barbara, Marzolini Catia, Thurnheer Christine, Seneghini Marco, Bernasconi Enos, Cavassini Matthias, Buvelot Hélène, Kouyos Roger, Günthard Huldrych F, Fellay Jacques, Tarr Philip E

Abstract excerpt

BACKGROUND: Coronary artery disease (CAD) is in part genetically determined. Aging is accentuated in people with human immunodeficiency virus (HIV) (PLWH). It is unknown whether genetic CAD event prediction in PLWH is improved by applying individual polygenic risk scores (PRSs) and by considering genetic variants associated with successful aging and longevity. METHODS: In the Swiss HIV Cohort Study participants...

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PMID: 34091660
DOI: 10.1093/cid/ciab521

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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