Article
Different diabetes types and pancreatic ductal adenocarcinoma: a Mendelian randomization and pathway/gene-set analysis.
Journal of the National Cancer Institute - 1 Mar 2026
Zhang Ting, Hua Xing, Mohindroo Chirayu, Wang Xiaoyu, Dutta Diptavo, Liu Jia, Katta Shilpa, Li Shengchao A, Wang Jiahui, Antwi Samuel O, Arslan Alan A, Beane Freeman Laura E, Bracci Paige M, Canzian Federico, Du Mengmeng, Gallinger Steven, Goodman Phyllis J, Katzke Verena, Kooperberg Charles, Le Marchand Loic, Neale Rachel E, Patel Alpa V, Perdomo Sandra, Shu Xiao-Ou, Visvanathan Kala, Van Den Eeden Stephen K, White Emily, Zheng Wei, Albanes Demetrius, Andreotti Gabriella, Bamlet William R, Brennan Paul, Buring Julie E, Chanock Stephen J, Chen Yu, Darst Burcu, Ferrari Pietro, Giovannucci Edward L, Goggins Michael, Haiman Christopher, Hassan Manal, Holly Elizabeth A, Hung Rayjean J, Jones Miranda R, Kraft Peter, Kurtz Robert C, Malats Núria, Moore Steven C, Ng Kimmie, Oberg Ann L, Orlow Irene, Peters Ulrike, Porta Miquel, Rabe Kari G, Rothman Nathaniel, Sánchez Maria-José, Sesso Howard D, Silverman Debra T, Southey Melissa C, Um Caroline Y, Yarmolinsky James, Yu Herbert, Yuan Chen, Zhong Jun, Wolpin Brian M, Risch Harvey A, Amundadottir Laufey T, Klein Alison P, Yu Kai, Zhang Haoyu, Stolzenberg-Solomon Rachael Z
Abstract excerpt
BACKGROUND: The associations between different types of diabetes, characterized by distinct pathophysiology and genetic architecture, and pancreatic ductal adenocarcinoma (PDAC) risk are not understood. METHODS: We investigated associations of genetic susceptibility to type 2 diabetes (T2D), 8 T2D mechanistic clusters, type 1 diabetes (T1D), and maturity-onset diabetes of the young (MODY) with PDAC risk. We used...
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