Article
Pathway analysis of genome-wide association study data highlights pancreatic development genes as susceptibility factors for pancreatic cancer.
Carcinogenesis - 1 Jul 2012
Li Donghui, Duell Eric J, Yu Kai, Risch Harvey A, Olson Sara H, Kooperberg Charles, Wolpin Brian M, Jiao Li, Dong Xiaoqun, Wheeler Bill, Arslan Alan A, Bueno-de-Mesquita H Bas, Fuchs Charles S, Gallinger Steven, Gross Myron, Hartge Patricia, Hoover Robert N, Holly Elizabeth A, Jacobs Eric J, Klein Alison P, LaCroix Andrea, Mandelson Margaret T, Petersen Gloria, Zheng Wei, Agalliu Ilir, Albanes Demetrius, Boutron-Ruault Marie-Christine, Bracci Paige M, Buring Julie E, Canzian Federico, Chang Kenneth, Chanock Stephen J, Cotterchio Michelle, Gaziano J Michael, Giovannucci Edward L, Goggins Michael, Hallmans Göran, Hankinson Susan E, Hoffman Bolton Judith A, Hunter David J, Hutchinson Amy, Jacobs Kevin B, Jenab Mazda, Khaw Kay-Tee, Kraft Peter, Krogh Vittorio, Kurtz Robert C, McWilliams Robert R, Mendelsohn Julie B, Patel Alpa V, Rabe Kari G, Riboli Elio, Shu Xiao-Ou, Tjønneland Anne, Tobias Geoffrey S, Trichopoulos Dimitrios, Virtamo Jarmo, Visvanathan Kala, Watters Joanne, Yu Herbert, Zeleniuch-Jacquotte Anne, Amundadottir Laufey, Stolzenberg-Solomon Rachael Z
Abstract excerpt
Four loci have been associated with pancreatic cancer through genome-wide association studies (GWAS). Pathway-based analysis of GWAS data is a complementary approach to identify groups of genes or biological pathways enriched with disease-associated single-nucleotide polymorphisms (SNPs) whose individual effect sizes may be too small to be detected by standard single-locus methods. We used the adaptive rank...
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