Article
Comparison of RNA- and DNA-based methods for measurable residual disease analysis in NPM1-mutated acute myeloid leukemia.
International journal of laboratory hematology - 1 Aug 2021
Pettersson Louise, Johansson Alm Sofie, Almstedt Alvar, Chen Yilun, Orrsjö Gustav, Shah-Barkhordar Giti, Zhou Li, Kotarsky Heike, Vidovic Karina, Asp Julia, Lazarevic Vladimir, Saal Lao H, Fogelstrand Linda, Ehinger Mats
Abstract excerpt
INTRODUCTION: Reverse transcriptase quantitative PCR (RT-qPCR) is considered the method of choice for measurable residual disease (MRD) assessment in NPM1-mutated acute myeloid leukemia (AML). MRD can also be determined with DNA-based methods offering certain advantages. We here compared the DNA-based methods quantitative PCR (qPCR), droplet digital PCR (ddPCR), and targeted deep sequencing (deep seq) with...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.