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Article

Minimal Residual Disease Monitoring of Acute Myeloid Leukemia by Massively Multiplex Digital PCR in Patients with NPM1 Mutations.

The Journal of molecular diagnostics : JMD - 1 Jul 2017

Mencia-Trinchant Nuria, Hu Yang, Alas Maria Antonina, Ali Fatima, Wouters Bas J, Lee Sangmin, Ritchie Ellen K, Desai Pinkal, Guzman Monica L, Roboz Gail J, Hassane Duane C

Abstract excerpt

The presence of minimal residual disease (MRD) is widely recognized as a powerful predictor of therapeutic outcome in acute myeloid leukemia (AML), but methods of measurement and quantification of MRD in AML are not yet standardized in clinical practice. There is an urgent, unmet need for robust and sensitive assays that can be readily adopted as real-time tools for disease monitoring. NPM1 frameshift mutations...

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Topics

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Share to Cell Line, Tumor
Share to Cells, Cultured

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leukemia, Myeloid, Acute

Share to Multiplex Polymerase Chain Reaction

Share to Neoplasm, Residual

Share to Nuclear Proteins

Share to Nucleophosmin

Source

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Identifiers

PMID: 28525762
DOI: 10.1016/j.jmoldx.2017.03.005
PMCID: PMC5500824

Genes

NPM1

Provenance

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