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Article

N1 and N2 neutrophil phenotypes may play differential roles in stimulating the endochondral ossification behaviors of ATDC5 cells.

Gene - 15 Jan 2026

Lu Fangzhou, Cremers Andy, Poeze Martijn, van Griensven Martijn, Welting Tim J M, Blokhuis Taco J, Caron Marjolein M J

Abstract excerpt

OBJECTIVE: Endochondral ossification is vital for bone healing, with neutrophils playing a crucial role in the osteoimmune system. While N1 (pro-inflammatory) and N2 (regenerative) neutrophils are documented in other contexts, their role in endochondral ossification remains unclear. This study investigates their effects on ATDC5 cells. METHODS: Neutrophils from five healthy volunteers were isolated and polarized...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41197999
DOI: 10.1016/j.gene.2025.149874

Genes

COL10A1
COL1A1
COL2A1
RUNX2
SOX9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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