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Article

Is there a role for N1-N2 neutrophil phenotypes in bone regeneration? A systematic review.

Bone - 1 Apr 2024

Lu Fangzhou, Verleg Samai M N E, Groven Rald V M, Poeze Martijn, van Griensven Martijn, Blokhuis Taco J

Abstract excerpt

PURPOSE: This review aims to provide an overview of the multiple functions of neutrophils, with the recognition of the inflammatory (N1) and regenerative (N2) phenotypes, in relation to fracture healing. METHODS: A literature search was performed using the PubMed database. The quality of the articles was evaluated using critical appraisal checklists. RESULTS: Thirty one studies were included in this review. These...

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PMID: 38253189
DOI: 10.1016/j.bone.2024.117021

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