Mesenchymal stromal cells modulate neutrophil phenotype via paracrine signals.

doi:10.1186/s13287-025-04684-w

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Mesenchymal stromal cells modulate neutrophil phenotype via paracrine signals.

Stem cell research & therapy - 21 Oct 2025

Cherry Laudy, Popescu Sinziana, Neculachi Carmen Alexandra, Nastase-Rusu Evelyn-Gabriela, Marinescu-Colan Catalina Iolanda, Cosman Bogdan Paul, Ciortan Letitia, Martelli Fabio, Simionescu Maya, Butoi Elena, Burlacu Alexandrina, Preda Mihai Bogdan

Abstract excerpt

BACKGROUND: Despite the recognized importance of neutrophils in cardiac repair following myocardial infarction (MI), their interaction with mesenchymal stromal cells (MSCs), particularly regarding polarization phenotypes and functional impacts, remains unclear. Here, we investigated these interactions across controlled in vitro systems and an in vivo MI model. METHODS: Human HL-60 cells were differentiated into...

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Topics

Mesenchymal Stem Cells
Humans
Animals
Neutrophils
Paracrine Communication

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Mice

Myocardial Infarction

HL-60 Cells

Phenotype

Mesenchymal Stem Cell Transplantation

Cell Differentiation

Male

Coculture Techniques

Source

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Identifiers

PMID: 41121373
DOI: 10.1186/s13287-025-04684-w
PMCID: PMC12539047

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