Phenotypic Landscape of Pulmonary Neuroendocrine Tumors: Subtyped by OTP/ASCL1 Expression Correlated with Histology, Hormones and Outcome.

doi:10.1007/s12022-025-09882-z

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Article

Phenotypic Landscape of Pulmonary Neuroendocrine Tumors: Subtyped by OTP/ASCL1 Expression Correlated with Histology, Hormones and Outcome.

Endocrine pathology - 6 Nov 2025

Ura Ayako, Evert Katja, Evert Matthias, Märkl Bruno, Kremer Marcus, Moser Elisa, Sasano Hironobu, Okada Yoshinori, Steiger Katja, Mogler Carolin, Jesinghaus Moritz, von Werder Alexander, Safi Seyer, Hoffmann Hans, Klöppel Günter, Kasajima Atsuko

Abstract excerpt

Recent studies have shown that pulmonary neuroendocrine tumor (NET) subgroups, defined by the transcription factors OTP and ASCL1, correlate with age, sex, and tumor location. Their relationships with histology and hormone production, however, remain unclear. We analyzed 170 pulmonary NETs classified by OTP (O) and ASCL1 (A) expression into four groups: O + /A + , O + /A-, O-/A + , and O-/A-. Subgroups were...

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Topics

Humans
Female
Neuroendocrine Tumors
Male
Aged

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Lung Neoplasms

Middle Aged

Basic Helix-Loop-Helix Proteins

Biomarkers, Tumor

Adult

Aged, 80 and over

Phenotype

Nerve Tissue Proteins

Homeodomain Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 41196447
DOI: 10.1007/s12022-025-09882-z
PMCID: PMC12592246

Genes

OTP
ASCL1
DLL3
GRP

Provenance

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