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Article

Oncogenic Mutation BRAF V600E Changes Phenotypic Behavior of THLE-2 Liver Cells through Alteration of Gene Expression.

International journal of molecular sciences - 28 Jan 2022

Śmiech Magdalena, Leszczyński Paweł, Wardell Christopher, Poznański Piotr, Pierzchała Mariusz, Taniguchi Hiroaki

Abstract excerpt

The accumulation of mutations in cancer driver genes, such as tumor suppressors or proto-oncogenes, affects cellular homeostasis. Disturbances in the mechanism controlling proliferation cause significant augmentation of cell growth and division due to the loss of sensitivity to the regulatory signals. Nowadays, an increasing number of cases of liver cancer are observed worldwide. Data provided by the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35163468
DOI: 10.3390/ijms23031548
PMCID: PMC8836259

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