Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional genomics and tumor microenvironment analysis reveal prognostic biological subtypes in Mantle cell lymphoma.

Nature communications - 5 Nov 2025

Sharma Sunandini, Ali Roshia, Bouska Alyssa, Jochum Dylan, Kesireddy Meghana, Mahov Simeon, Lownik Joseph, Zhang Weiwei, Lone Waseem, Soma Mahfuza Afroz, Gamboa Alicia, Devarakonda Vaishnavi, El-Gamal Dalia, Fariha Atqiya, Mansoor Adnan, Stewart Douglas, Martin Peter, Link Brian K, Advani Ranjana H, Barr Paul M, Goy Andre H, Mehta Amitkumar, Kamdar Manali, Stephens Deborah M, Bachanova Veronika, Smith Lynette, Morin Ryan, Pararajalingam Prasath, Lunning Matthew A, Fu Kai, Weisenburger Dennis, Chan Wing C, Khoury Joseph, Greiner Timothy C, Vose Julie M, Merchant Akil, Bi Chengfeng, Iqbal Javeed

Abstract excerpt

Mantle cell lymphoma (MCL) is a genetically and clinically heterogeneous B-cell malignancy. We studied two MCL cohorts with differing treatment patterns: one enriched for immunochemotherapy, the other for chemotherapy alone. TP53 alterations are consistently associated with poor prognosis, whereas ATM mutations correlate with improved outcomes following rituximab-based chemotherapy. Based on recurrent genetic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Ataxia Telangiectasia Mutated Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Profiling

Share to Gene Expression Regulation, Neoplastic

Share to Genomics

Share to Lymphoma, Mantle-Cell

Share to Rituximab

Share to Tumor Microenvironment

Share to Tumor Suppressor Protein p53

Source

Open in PubMed Open full text

Identifiers

PMID: 41193463
DOI: 10.1038/s41467-025-64666-7
PMCID: PMC12589501

Genes

TP53
ATM
BCR
CD4
PTPN6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional genomics and tumor microenvironment analysis reveal prognostic biological subtypes in Mantle cell lymphoma.PMID 41193463Read ↗

Functional genomics and tumor microenvironment analysis reveal prognostic biological subtypes in Mantle cell lymphomaSemantic proximity Read ↗

Exploiting gene mutations and biomarkers to guide treatment recommendations in mantle cell lymphoma.Semantic proximity Read ↗

Longitudinal single-cell profiling reveals molecular heterogeneity and tumor-immune evolution in refractory mantle cell lymphomaSemantic proximity Read ↗

Genetic mutations and features of mantle cell lymphoma: a systematic review and meta-analysis.Semantic proximity Read ↗

Biological and clinical determinants shaping heterogeneity in mantle cell lymphomaSemantic proximity Read ↗

Mantle Cell Lymphoma Under the Scope of Personalized Medicine: Perspective and Directions.Semantic proximity Read ↗

Surveying the Genomic Landscape of Mantle Cell Lymphoma Indicates the Importance of Multimodal Genomic and Transcriptomic ExplorationSemantic proximity Read ↗

Your chemo is no good here: management of high-risk MCL.Semantic proximity Read ↗

Genomic landscape and prognostic analysis of mantle cell lymphoma.Semantic proximity Read ↗

Landscape of somatic mutations and clonal evolution in mantle cell lymphoma.Semantic proximity Read ↗

Mantle cell lymphoma: biology, pathogenesis, and the molecular basis of treatment in the genomic eraSemantic proximity Read ↗

Genomic and epigenomic insights into the origin, pathogenesis, and clinical behavior of mantle cell lymphoma subtypes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.