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Article

AXIN2 variants, tooth agenesis, and cancer risk: a systematic review.

BMC oral health - 4 Nov 2025

Ratanasereeprasert Nutthakarn, Intarak Narin, Chaweewannakorn Chayanit, Abid Mushriq, Marya Anand, Cho Sung-Dae, Porntaveetus Thantrira

Abstract excerpt

BACKGROUND: Variants in the Axis Inhibition Protein 2 (AXIN2) have been associated with tooth agenesis, a congenital condition characterized by missing teeth, and an increased risk of various cancers. Studies suggest that individuals with AXIN2 variants may exhibit both dental anomalies and a predisposition to malignancies, particularly colorectal cancer. This raises the possibility that tooth agenesis could...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41188821
DOI: 10.1186/s12903-025-07022-x
PMCID: PMC12584280

Genes

AXIN2
SMAD3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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