Article
The Augmented Classical Twin Design: Incorporating Genome-Wide Identity by Descent Sharing Into Twin Studies in Order to Model Violations of the Equal Environments Assumption.
Behavior genetics - 1 May 2021
Hwang Liang-Dar, Mitchell Brittany L, Medland Sarah E, Martin Nicholas G, Neale Michael C, Evans David M
Abstract excerpt
The Classical Twin Method (CTM) compares the similarity of monozygotic (MZ) twins with that of dizygotic (DZ) twins to make inferences about the relative importance of genes and environment in the etiology of individual differences. The design has been applied to thousands of traits across the biomedical, behavioral and social sciences and is arguably the most widely used natural experiment known to science. The...
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