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NEK8 promotes the progression of gastric cancer by reprogramming asparagine metabolism

6 Jan 2025

Abstract excerpt

Several members of the NIMA-related kinase (NEK) family have been implicated in tumor progression; however, the role and underlying mechanisms of NEK8 in gastric cancer (GC) remain unclear. This study revealed a significant upregulation of NEK8 in GC, identifying it as an independent prognostic marker in patients with GC. Consistent with these findings, NEK8 silencing substantially impeded GC aggressiveness both...

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PMID: 39762761
DOI: 10.1186/s10020-024-01062-9

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