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Article

Sequence homology between sex chromosomes leads to apparent heterozygosity at the DYS572 locus in massively parallel sequencing.

International journal of legal medicine - 1 Mar 2026

Liu Zhiyong, Hu Lan, Sun Hui, Lu Xiaoyu, Li Ran, Ma Xiaoyan, Lei Bo, Sun Hongyu, Liu Chao

Abstract excerpt

In forensic genetics, Y-chromosomal short tandem repeats (Y-STRs) are widely used in male lineage tracing, kinship analysis, and mixture interpretation. Conventional genotyping of Y-STRs relies on length-based detection via capillary electrophoresis (CE). However, massively parallel sequencing (MPS) enables simultaneous determination of both length and sequence genotypes, thereby increasing the information...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 41184531
DOI: 10.1007/s00414-025-03643-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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