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The Contribution of Massively Parallel Sequencing in Disclosing Unusual Tri- and Tetra-Allelic Type Patterns Detected at the Multicopy Loci DYS385a/b and DYF387S1.

International journal of molecular sciences - 6 Mar 2026

Saccardo Chiara, De Leo Domenico, Turrina Stefania

Abstract excerpt

Atypical allelic patterns with additional alleles at multicopy Y-short tandem repeats (Y-STRs), such as DYS385a/b and DYF387S1, mainly arise from duplication or gene conversion events occurring in the palindromic regions of the Y chromosome where these markers are located. Although rarely encountered in forensic genetics, these allelic patterns require accurate deconvolution of the single allelic components to...

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Alleles
Chromosomes, Human, Y
Genetic Loci
High-Throughput Nucleotide Sequencing
Microsatellite Repeats

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Sequence Analysis, DNA

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PMID: 41828650
DOI: 10.3390/ijms27052434
PMCID: PMC12986293

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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