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Stable Hypermutators Revealed by the Genomic Landscape of Genes Involved in Genome Stability Among Yeast Species.

Molecular biology and evolution - 29 Oct 2025

Gonçalves Carla, Steenwyk Jacob L, Rinker David C, Opulente Dana A, LaBella Abigail L, Harrison Marie-Claire, Wolters John F, Zhou Xiaofan, Shen Xing-Xing, Covo Shay, Groenewald Marizeth, Hittinger Chris Todd, Rokas Antonis

Abstract excerpt

Mutator phenotypes are short-lived due to the rapid accumulation of deleterious mutations. Yet, recent observations reveal that certain fungi can undergo prolonged accelerated evolution after losing genes involved in DNA repair. Here, we surveyed 1,154 yeast genomes representing nearly all known yeast species of the subphylum Saccharomycotina (phylum Ascomycota) to examine the relationship between reduced gene...

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Identifiers

PMID: 41178256
DOI: 10.1093/molbev/msaf285
PMCID: PMC12629084

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