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Genomic Profiles as Predictors of Occult Lymph Node Metastasis and Clinical Outcomes in Early-Stage Clinical N0 Non-Small Cell Lung Cancer.

Clinical lung cancer - 1 Apr 2026

Takemura Chihiro, Yoshida Tatsuya, Yoshida Yukihiro, Higashiyama Ryoko Inaba, Horinouchi Hidehito, Igaki Hiroshi, Yamamoto Noboru, Ohe Yuichiro, Yatabe Yasushi, Watanabe Shun-Ichi

Abstract excerpt

OBJECTIVE: Occult lymph node (LN) metastasis, indicating pathological LN involvement, is often observed in clinical N0 (cN0) early-stage non-small cell lung cancer (NSCLC). Identifying preoperative predictors of occult LN metastasis (pathologically N1 and N2) is crucial for determining the surgical procedure for cN0 NSCLC. This study aimed to investigate the role of genetic mutations in predicting occult LN...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 41177713
DOI: 10.1016/j.cllc.2025.10.002

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EGFR
ALK

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