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Article

Prediction of Lymph Node Metastasis in Non-Small Cell Lung Carcinoma Using Primary Tumor Somatic Mutation Data.

JCO clinical cancer informatics - 1 Jun 2025

Lee Victor, Moore Nicholas S, Doyle Joshua, Hicks Daniel, Oh Patrick, Bodofsky Shari, Hossain Sajid, Patel Abhijit A, Aneja Sanjay, Homer Robert, Park Henry S

Abstract excerpt

PURPOSE: Lymph node metastasis (LNM) significantly affects prognosis and treatment strategies in non-small cell lung cancer (NSCLC). Current diagnostic methods, including imaging and histopathology, have limited sensitivity and specificity. This study aims to develop and evaluate machine learning (ML) models that predict LNM in NSCLC using single-nucleotide polymorphism (SNP) data from The Cancer Genome Atlas....

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Identifiers

PMID: 40446175
DOI: 10.1200/CCI-24-00303

Genes

CENPF
KCNT2

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