Article
RAISE: A computational tool for evaluating sarbecovirus spillover potential.
Nature communications - 25 Apr 2026
Huang He, Kong Lupeng, Zhu Yanzhi, Dai Yue, Yang Yutong, Wang Yuyang, Wu Zhiqiang, Gao Yi Qin, Ren Lili
Abstract excerpt
Animal sarbecoviruses, relatives of SARS-CoV or SARS-CoV-2, pose a significant zoonotic threat driven by their ability to bind the human ACE2 (hACE2) receptor. To address challenges in evaluating these threats, we developed RAISE (Receptor binding domain-hACE2 Interaction Scoring Evaluation), a computational framework that integrates structural predictions with interaction scoring. By scoring predicted hACE2...
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