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Article

Mouse ataxin-3 functional knock-out model.

Neuromolecular medicine - 1 Mar 2011

Switonski Pawel M, Fiszer Agnieszka, Kazmierska Katarzyna, Kurpisz Maciej, Krzyzosiak Wlodzimierz J, Figiel Maciej

Abstract excerpt

Spinocerebellar ataxia 3 (SCA3) is a genetic disorder resulting from the expansion of the CAG repeats in the ATXN3 gene. The pathogenesis of SCA3 is based on the toxic function of the mutant ataxin-3 protein, but the exact mechanism of the disease remains elusive. Various types of transgenic mous...

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Identifiers

PMID: 20945165
DOI: 10.1007/s12017-010-8137-3
PMCID: PMC3044828

Genes

ATXN3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20945165-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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