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Article

A CRISPR activation screen reveals a cilia disassembly pathway mutated in focal cortical dysplasia.

Science advances - 31 Oct 2025

Elliott Shane D, Ready Paul J, Wrinn Caitlin M, Ma Qianqian, Edward Marina, Niescier Robert F, Escobar Iris, Sun Jingbo, Ganga Anil Kumar, McAtee Ceara K, Atiş İrem Sude, Koleske Anthony J, Bordey Angélique, Breslow David K

Abstract excerpt

Defective assembly of primary cilia causes ciliopathies, but cilia disassembly and its role in disease remain poorly understood. From a genome-wide CRISPR activation (CRISPRa) screen for negative regulators of ciliary function, we find here that the F2R G protein-coupled receptor, sterile alpha and TIR motif-containing 1 (SARM1) hydrolase, ryanodine receptors, peri-centrosomal calcium signaling, and RhoA form a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41160700
DOI: 10.1126/sciadv.aeb7238
PMCID: PMC12571082

Genes

SARM1
F2R

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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