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Asiatic Acid from Centella asiatica as a Potent EGFR Tyrosine Kinase Inhibitor with Anticancer Activity in NSCLC Cells Harboring Wild-Type and T790M-Mutated EGFR.

Biomolecules - 3 Oct 2025

Monmai Chaiwat, Sabuakham Sahachai, Pabuprapap Wachirachai, Chaichompoo Waraluck, Suksamrarn Apichart, Mahalapbutr Panupong

Abstract excerpt

Lung cancer is a leading cause of cancer mortality worldwide. Targeted therapies with epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) represent a significant advance in the management of lung cancer. However, their long-term efficacy is often limited by acquired resistance, particularly due to the T790M mutation, highlighting the need for novel EGFR-TKIs. Although compounds derived from...

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PMID: 41154639
DOI: 10.3390/biom15101410
PMCID: PMC12563520

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EGFR

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