Article
The marine-derived pachycladin diterpenoids as novel inhibitors of wild-type and mutant EGFR.
Biochemical pharmacology - 15 Feb 2017
Mohyeldin Mohamed M, Akl Mohamed R, Siddique Abu Bakar, Hassan Hossam M, El Sayed Khalid A
Abstract excerpt
Epidermal growth factor receptor (EGFR) is a key player in proliferation and metastasis of various cancers. Discovery of novel EGFR inhibitors is still an urgent clinical oncology unmet need. Pachycladins are eunicellin-based diterpenoids isolated from the soft coral Cladiella pachycladous species. This study evaluated the anticancer activity of pachycladins A-E against diverse breast and cervical cancer cells....
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