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Oleandrin-mediated suppression of MELK induces apoptosis, autophagy, and ferroptosis in human non-small cell lung cancer cells

18 Aug 2025

Abstract excerpt

BACKGROUND: Non-small-cell lung cancer NSCLC is the major diagnosed type of lung cancers in the USA and Europe. It is generally related to poor prognosis and low rates of survival. Oleandrin is a cardiac glycoside occurring naturally in Nerium oleander (Apocynaceae). PURPOSE: To explore the potential therapeutic value of oleandrin against different cancer types with emphasis on NSCLC. METHODS: The effect of...

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Cancer Mechanisms and Therapy
Ferroptosis and cancer prognosis
FOXO transcription factor regulation

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 40916237
DOI: 10.1016/j.phymed.2025.157173

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